Adipocytokines and Insulin Resistance across Various Degrees of Glucose Tolerance in Pregnancy
نویسندگان
چکیده
منابع مشابه
Adipocytokines and Insulin Resistance
I t is well known that adipocytes and resident macrophages that have migrated to adipose tissue produce and secrete a variety of biologically active mediators (adipocytokines), which are thought to contribute to the development of insulin resistance, type 2 diabetes, and cardiovascular disease (1). The abnormal function of adipocytes may play an important role in the development of a chronic lo...
متن کاملThe role of adipocytokines in insulin resistance in normal pregnancy: visfatin concentrations in early pregnancy predict insulin sensitivity.
BACKGROUND Throughout pregnancy maternal adipose tissue is metabolically active, producing adipocytokines involved in the process of insulin resistance. We explored the role of serum adipocytokines, including the newly identified adipocytokine visfatin, in the process of insulin resistance in normal pregnancy. METHODS We examined 80 pregnant nonobese, nondiabetic white women during the 3 trim...
متن کاملInsulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance.
OBJECTIVE To investigate the characteristics of isolated impaired glucose tolerance (IGT) and isolated impaired fasting glucose (IFG), we analyzed the factors responsible for elevation of 2-hour postchallenge plasma glucose (2 h PG) and fasting plasma glucose (FPG) levels. METHODS We investigated the relationship between 2 h PG and FPG levels who underwent 75 g OGTT in 5620 Japanese subjects ...
متن کاملAbnormal Glucose Tolerance and Insulin Resistance in Polycystic Ovary Syndrome
Background Insulin resistance and glucose dysmetabolism in polycystic ovary syndrome (PCOS) are related with the polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, especially Gly972Arg/Ala513Pro polymorphism being reported to be associated with type-2 diabetes and PCOS. We intended to assess the prevalence of abnormal glucose tolerance (AGT) and insulin resistanc...
متن کاملMaternal Glucose Tolerance in Pregnancy Affects Fetal Insulin Sensitivity
OBJECTIVE Offspring of mothers with impaired glucose tolerance are far more likely to develop type 2 diabetes. We tested the hypothesis that maternal glucose tolerance in pregnancy affects fetal insulin sensitivity or beta-cell function. RESEARCH DESIGN AND METHODS In a prospective singleton pregnancy cohort study, we analyzed glucose, insulin, and proinsulin concentrations in maternal blood ...
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ژورنال
عنوان ژورنال: Journal of International Medical Research
سال: 2012
ISSN: 0300-0605,1473-2300
DOI: 10.1177/147323001204000220